According to New York's Daily News the Tennessee MC and his entourage left the Chelsea club after an unpleasant exchange of words turned into real violence.
No injuries were reported as a result of the incident.
In related news, 50, who is engaged in a lyrical battle with Cam'ron, recently fired back at the DipSet rapper in Young Buck's "Hold On" video, which also surfaced on the internet on Friday.
At the end of the clip, 50 pokes fun at Cam's pink truck and claims the Harlem emcee has AIDS and not Irritable Bowel Syndrome (IBS).
"You taking about you got IBS, you got A-I-D-S, that's why they call you Killa," scoffs 50. "Fuck around and brush your teeth, your teeth bleeding, niggas drink behind you and have all kinds of shit. They show up 30 pounds lighter, taking about 'All I remember is I had a little bit of Cam Snapple.'"